The National Abandoned Infants Assistance Resource Center's mission is to enhance the quality of social and health services delivered to children who are abandoned or at-risk of abandonment due to the presence of drugs and/or HIV in the family. The Resource Center provides training, information, support, and resources to service providers who assist these children and their families.

In 1988, Congress passed the Abandoned Infants Assistance Act to address the "boarder baby" phenomenon, wherein infants, particularly those perinatally exposed to drugs or HIV, reside in hospitals indefinitely due to difficulties in locating appropriate living arrangements. This legislation, which is administered by the Children's Bureau, Administration on Children, Youth and Families, U.S. Department of Health and Human Services, provides funding to support the Resource Center and direct service projects.

The Resource Center is located at the University of California at Berkeley.